ABSTRACT
Introduction: Pancytopenia is a very common consequenceof many haematological diseases with extensive differentialdiagnosis. It is described as the deficiency of all three cellularelements of blood resulting in anemia and leucopenia andthrombocytopenia. The severity and underlying pathologydetermines the management and prognosis. Bone marrowexamination is an effective way of evaluating various causesof pancytopenia along with other clinical, haematologicalfindings.Material and methods: In this prospective study, a total60 patients presenting with pancytopenia on initial work uprequiring bone marrow examination were studied along withtheir relevant clinical history, examination findings, routinehaematological findings.Results: Among 60 cases studied, age of patients ranged from1-85 years with slight male predominance. Most commonage group involve was 11-30 years. Most of the patientspresented with generalised weakness, pallor, fever. Dimorphicanemia was the predominant blood picture. The commonestmarrow finding was hypercellularity with megaloblasticerythropoiesis. The commonest cause of pancytopenia wasmegaloblastic anemia 62.79% followed by sub/aleukemicleukemia 25.57%.Conclusions: Bone marrow examination can diagnosedmajority of cases of pancytopenia along with comprehensiveclinical and haematological study. It is also helpful in planningfurther investigations and management.